发明名称 |
PLASMINOGEN-ACTIVATING SUBSTANCE AND THE PREPARATION AND USE OF SUCH SUBSTANCE |
摘要 |
<p>A new type of plasminogen-activating substance is extracted from the bile of hogs. That substance is characterized by: (A) a molecular weight of 80,000 ? 10,000; (B) an isoelectric point of 7.1; (C) an ultraviolet absorption spectrum showing a peak (.lambda. max) at a wave length of 278 nm; (D) a fibrinolysis activity such that a Ca-added standard fibrin plate is lysed but a heated fibrin plate is not lysed; (E) such a high thermal stability that heating at a temperature of 80.degree.C. for 10 min-utes causes the plasminogen-activating activity to be decreased to an extent corresponding to 50% of the original activity and heating at a temperature of 60.degree.C. for 30 minutes causes the plasminogen-activating activity to be decreased to an extent corresponding to from 30 to 40% of the original activity; (F) a solubility in a salin solution and an insolubility in water-soluble organic solvents; and (G) a synthetic substratelysis activity such that Glutaryl-Gly-Arg-MCA and Pro-Phe-Arg-MCA are only marginally hydrolysed. Such substance can be used as an essential component of a therapeutic medicine for thrombosis.</p> |
申请公布号 |
CA1139661(A) |
申请公布日期 |
1983.01.18 |
申请号 |
CA19800348790 |
申请日期 |
1980.03.27 |
申请人 |
TOBISHI PHARMACEUTICAL CO., LTD. |
发明人 |
YAMASHINA, IKUO;KAWASAKI, TOSHISUKE;TSUKUDA, MICHIKO |
分类号 |
C07K1/20;A61K38/00;A61K38/46;A61P7/02;C07K14/435;C12N9/64;(IPC1-7):A61K35/413 |
主分类号 |
C07K1/20 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|