METHOD FOR MAKING OF CARBAMIDE DERIVATIVES

摘要

Urea derivatives of the formula (wherein Ar represents a residue of 5- or 6-membered heteroaromatic ring; R represents a hydrogen atom or a C1-C6 alkyl group; R1 represents a C1-C6 alkyl group; and R2 represents a C1-C6 alkyl, C2-C6 alkenyl, or C1-C6 alkoxy group) are produced by reacting an amine of the formula Ar-NH-R (wherein Ar and R have the significance given above) with a carbamoyl halogenide of the formula (wherein X represents a halogen atom, and R1 and R2 have the significance given above) in the presence of a Lewis acid in an inert solvent.