| 摘要 |
A method of producing morphinan compounds which incorporates double advantages over the prior art, such as the utilization of beta , gamma -unsaturated ketones in place of the alpha , beta -unsaturated ketones previously used. Additionally, in the step where beta , gamma -unsaturated bromoketones (13 or 14) proceed to 1-bromo-N-formylnordihydrothebainone (morphinan) (17) there are utilized super acids, such as trifluoromethane sulfonic, trifluoroethane sulfonic and mixtures thereof, and also antimony pentafluoride and mixtures of hydrogen fluoride and antimony pentafluoride. Super acid works, whereas the prior art shows that cyclization in the presence of acids, even strong acids, such as sulfuric, phosphoric, do not work.
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