| 摘要 |
PCT No. PCT/GB80/00001 Sec. 371 Date Sep. 3, 1980 Sec. 102(e) Date Sep. 3, 1980 PCT Filed Jan. 4, 1980 PCT Pub. No. WO80/01381 PCT Pub. Date Jul. 10, 1980.Novel bicyclo [2,2,1] heptanes and hept-2Z-enes are substituted at the 5-position by a 6-carboxyhex-2-enyl group or a modification thereof, and at the 6-position by an aldoxime or ketoxime group which is O-substituted by an aliphatic hydrocarbon residue, an aromatic residue, or an aliphatic hydrocarbon residue substituted directly or through an oxygen or sulphur atom by an aromatic residue. Such compounds may be prepared by the action of an oximating agent on an intermediate which is substituted at the 6-position by an aldehydic or ketonic carbonyl group. The compounds are of value for use in pharmaceutical compositions particularly in the context of the inhibition of thromboxane activity.
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