| 摘要 |
<p>Polypeptides having the formula: R1-Lys-Lys-X-R2 I wherein R1 is hydrogen or p-Glu; X is Glu or Asp; and R2 is NH2, Val-NH2 or Val-OH, and pharmaceutically acceptable salts have the capability of inducing the maturation of T-cell populations and thus are useful in a number of therapeutic areas. <??>They are prepared by classical or solid phase synthetic methods via appropriate protected peptide intermediates having the formula: <CHEM> wherein R3 is R1 or an alpha -amino protecting group, A and A1 are independently hydrogen or protecting groups for the epsilon -amino group of lysine, B is a protecting group for the carboxyl of glutamic or aspartic acid, n is 0 or 1 and R4 is NH2 or a benzydrylamine resin support or when n is 1 R4 also represents OR5 where R5 is hydroxy, a carboxy protecting group or -CH2[polystyrene resin support] with the proviso that when R<4> is amino or OH at least one of R3, A, A1 and B is a protecting group. Pharmaceutical compositions are also disclosed. </p> |
