4,4-DISUBSTITUTED-1-SULFO-2-OXOAZETIDINE DERIVATIVE AND ITS PREPARATION

摘要

NEW MATERIAL:A compound of formulaI(R and R<0> are organic residue linked to the carbon atom; R<1> is amino group which may be acylated or protected; X is H or methoxyl). EXAMPLE:Sodium 3-[2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-4,4- dimethyl-2-oxoazetidine-1-sulfonate. USE:Useful as a remedy for bacterial infection of men and domestic animals having the activity against Gram-positive and Gram-negative bacteria and also as a germicide. PROCESS:A compound of formula II is sulfonated with acetic anhydride or a reactive derivative thereof at 10-60 deg.C to give the compound of formulaI. The compound of formula II is prepared by using a 2-oxoazetidine of formula VI as a starting raw material according to the reaction formulas.