| 摘要 |
<p>NEW MATERIAL:A compound shown by formula I (R1 and R5 are CH3 or OCH3; R2 and R4 are CH3 or H; R3 is CH3 or OCH3; R6 is H or alpha-amino protecting group) and a salt thereof. USE:An intermediate for producing peptide. PREPARATION:alpha-Amino group of arginine is protected with carbobenzoxy group, etc., and the resultant substance is reacted with a halogenide containing a substituted benzenesulfonyl group shown by formula II at -5-10 deg.C to give a compound shown by formula I. The reaction is preferably carried out in the presence of a base such as NaOH, etc., in a solvent such as water, acetone, DMF or THF.</p> |
