发明名称 VERFAHREN ZUR HERSTELLUNG VON L-(ALPHA)-METHYLPHENYLALANINEN
摘要 Biochemical optical resolution of DL- alpha -methylphenyl alanines in which DL- alpha -methylphenyl alanine amides are interacted with the culture products, or their treated products, of a microorganism capable of producing amidase is described. L- alpha -methylphenyl alanines having the general formula (I): <IMAGE> [I] wherein R1 and R2 may be independently a hydrogen atom or lower alkyl groups, or R1 and R2 may be alkylene groups combined together to form 5 through 8-membered rings is produced by the steps of: (a) making a DL- alpha -methylphenyl alanine amide having the general formula (II): <IMAGE> [II] wherein R1 and R2 are the same as defined above, interact with the culture product of a microorganism capable of producing enzyme catalyzing the hydrolysis of L-isomer of DL- alpha -methylphenyl alanine amides or the treated product thereof, whereby asymmetric hydrolysis of an L- alpha -methylphenyl alanine amide is effected; and (b) separating the resultant L- alpha -methylphenyl alanines from the hydrolysis mixture.
申请公布号 DE3217908(A1) 申请公布日期 1982.12.23
申请号 DE19823217908 申请日期 1982.05.12
申请人 UBE INDUSTRIES, LTD., UBE, YAMAGUCHI, JP 发明人 OSHIMA, TOKIO;KIMURA, TOMIO;IWAMOTO, NORITADA;OMATA, TETSUO, UBE, YAMAGUCHI, JP
分类号 C12P13/02;C12N9/80;C12P13/04;C12P41/00;C12R1/01;C12R1/06;C12R1/07;C12R1/32;C12R1/365;C12R1/38;C12R1/465;C12R1/645;C12R1/72;C12R1/78;C12R1/845;C12R1/88;C12R1/885 主分类号 C12P13/02
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