Optically active 1-aromatic-group-substituted-1-alkanones and methods for their manufacture.

摘要

A manufacturing method is described for the preparation of optically active 1-aromatic-group-substituted-l-alkanones of the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="14" wi="30" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein Ar is an atomic group, X is hydrogen or sulfonyloxy and R is a saturated aliphatic group. An optically active alkane acid halide of the formula
<Chemistry id="chema02" num="0002"><Image id="ia02" he="15" wi="26" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein Y is halogen, is allowed to react with an aromatic compound in the presence of a Lewis acid. The optically active 1-aromatic-group-substituted-1-alkanones are useful intermediates in the preparation of optically active alpha-arylalkanoic acids, which are useful as pharmaceutical, e.g. anti-inflammatory, analgesic and anti-pyretic, agents and as insecticidal agents.