IMPROVED METHOD FOR PREPARING PLASMINOGEN ACTIVATOR, ACTIVATOR THUS OBTAINED AND MEDICINE COMPRISING IT

摘要

The present invention relates to an improved process for the preparation of plasminogen activator. This is a process for separating a plasminogen activator according to U.S. Pat. No. 3,998,947 characterized in that it comprises at least the following stages: (i) selective adsorption of the said activator on a support with specific affinity comprising soluble fragments of fibrin covalently bonded to an insoluble matrix; and (ii) elution of the activator from the fibrin bearing the adsorbed activator. The plasminogen activator obtained is useful in the prevention and treatment of thrombosis.