| 摘要 |
6-Acylaminomethyl-2-amino-4-hydroxy pyrimido(4,5-6)thiazines of formula (I) are new, R1 and R2 = H or 1-3 Alkyl, or CR1R2 = 3-7C cycloalkylidene; R3 = 2-4C alkanoyl, 1-4C alkylsulphonyl, C0Ar or S02Ar; Ar = phenyl opt substd by 1 or 2 or 1-3C alkyl, N02, F, Cl and Br. USE - (I) are dihydroneopterin aldolase and/or hydroxymethyl dihydropterin pyrophosphokinase inhibitors useful as components of antimalarial medicaments also contg dihydrofolate reductase and/or dihydropteroate synthase inhibitors.
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| 申请人 |
DR. KARL THOMAE GMBH, 7950 BIBERACH, DE |
发明人 |
PIEPER, HELMUT, DIPL.-CHEM. DR., 7950 BIBERACH, DE;SEYDEL, JOACHIM K., PROF., DIPL.-CHEM., DR., 2061 BORSTEL, DE;WALTER, ROLF D., DR., 2000 HAMBURG, DE;JUNG, ALBRECHT, DR., 7400 TUEBINGEN, DE |
