发明名称 |
FORFARANDE FOR FRAMSTELLNING AV 1-ALKYL-6,7-METYLENDIOXI-4(1H)-OXO-CINNOLIN-3-KARBOXYLSYROR |
摘要 |
A method is disclosed for production of 1-alkyl-4(1H)-oxo-cinnolin-3-carboxylic acids. Mesoxalic acid dialkylester-3,4-methylenedioxy-phenylhydrazone is saponified using 1 to 1.5 Mol alkali into the corresponding monoalkylester, which is cyclicized with a Friedel-Crafts catalyst in the presence of a carboxylic acid anhydride into 6,7-methylenedioxy-4(1H)-oxo-cinnolin-3-carboxylic acid alkylester, which is alkylated with a C1-C4 alkyl halogenide in the presence of alkali in a suitable solvent, after which the ester is saponified. Small amounts of byproduct alkylated in the 2-position are removed by brief heating and precipitation from alkaline solution, leaving a pure 1-alkyl product. The product is useful for the treatment of urinary tract infections. |
申请公布号 |
SE8207309(D0) |
申请公布日期 |
1982.12.21 |
申请号 |
SE19820007309 |
申请日期 |
1982.12.21 |
申请人 |
VEB ARZNEIMITTELWERK DRESDEN |
发明人 |
1)H-J * SCHMIDT;2)J * FRANKE;3)R * SCHEFFLER;4)H * TONJES;5)G * KAMMANN;6)G * DIETZ |
分类号 |
C07D317/66;C07D491/04;C07D491/056 |
主分类号 |
C07D317/66 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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