| 摘要 |
1495680 1 - (2 - Benzoylphenoxy) - 2 - hydroxy-3-aminopropanes MAY & BAKER Ltd 16 June 1976 [20 June 1975] 26407/75 Heading C2C Novel compounds of Formula I (wherein R<SP>1</SP> represents an isopropyl, t-butyl or 2-phenylethyl group, R<SP>2</SP> represents a methyl group or a chlorine atom, n represents 1 or 2 and m represents 0, 1 or 2) and non-toxic acid addition salts thereof where it is to be understood that when m represents 2 then the substitutents represented by the symbol R<SP>2</SP> may be the same or different are prepared by reaction of a compound of Formula II with an amine R<SP>1</SP>NH 2 . Intermediates of Formula II above are prepared from compounds of Formula IV with epichlorohydrin. Phenols of Formula IV are prepared by Fries rearrangement of the substituted benzoyloxy compounds prepared by acylation of the unsubstituted phenols. Pharmaceutical compositions in conventional forms for oral or parenteral administration and having vascular #-andrenoceptor blocking activity comprise an above novel compound and a carrier or diluent. |
