发明名称 |
PROLINDERIVAT OCH FORFARANDE FOR FRAMSTELLNING DERAV |
摘要 |
Proline derivatives of the formula (I): <IMAGE> (wherein R is an acyl group bonded to the alpha -amino group of amino acid A and is selected from the group consisting of cyclopropanecarbonyl, cyclohexanecarbonyl and adamantanecarbonyl groups; A is glycine, sarcosine or alpha -D-amino acid residue the carbonyl group of which forms a thiol ester bond with the sulfur atom) or a pharmaceutically acceptable salt thereof, and a process for producing the same are disclosed. The proline derivatives are useful for treating hypertension due to angiotensin II, and as an agent to treat cardiac insufficiency. |
申请公布号 |
SE8203814(L) |
申请公布日期 |
1982.12.20 |
申请号 |
SE19820003814 |
申请日期 |
1982.06.18 |
申请人 |
CHUGAI PHARMACEUTICAL CO LTD |
发明人 |
TANAKA S;KUROMARU K;FUJIMURA Y;MATSUNAGA I;IWAOKA T;OBATAKE N;AONO J;HINOHARA Y;NAKANO H;FUKUSHIMA M;NABATA H;SAKAI K;HATA S-I |
分类号 |
B65H19/28;C07D207/08;C07D207/12;C07D207/16;C07D209/20;C07D403/12;(IPC1-7):C07C103/52;C07K5/00 |
主分类号 |
B65H19/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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