DETECTION OF 3'-AZIDO-3'-DEOXYTHYMIDINE RESISTANCE
摘要
An assay for detecting the genotype of mutant and wild-type alleles at multiple loci associated with resistance to the drug AZT utilizes a series of probes which anneal to an amplified region of the HIV-1 pol gene. The assay format which involves amplification of a rare nucleic acid followed by capture on a solid phase, and detection of the captured sequences by a labelled probe, is applicable to assays for resistance to other drugs involving point mutations.
申请公布号
WO9216180(A2)
申请公布日期
1992.10.01
申请号
WO1992US02037
申请日期
1992.03.12
申请人
SISKA DIAGNOSTICS, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA