发明名称 |
Diagnostic radiopharmaceuticals for localization in target tissues exhibiting a regional pH shift relative to surrounding tissues |
摘要 |
A radiopharmaceutical chemical compound comprising a radioactive isotope, other than an isotope of iodine, in chemical combination with at least one amine group. The compound has a lipophilicity sufficiently high at a pH of 7.6 to permit passage of the compound from the blood of a mammal into a target organ or tissue and sufficiently low at a pH of 6.6 to prevent rapid return of the compound from the target organ or tissue to the blood. The compound has a percent protein binding of less than ninety percent. A method for selectively depositing a radiopharmaceutical compound in at least one target tissue or organ of a mammal, which tissue or organ has a significantly different intracellular pH than the blood of the mammal, by introducing the compound of the invention into the bloodstream of the mammal.
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申请公布号 |
US4363793(A) |
申请公布日期 |
1982.12.14 |
申请号 |
US19800174491 |
申请日期 |
1980.08.08 |
申请人 |
STATE UNIVERSITY OF NEW YORK |
发明人 |
BLAU, MONTE;KUNG, HANK F. |
分类号 |
A61K51/04;(IPC1-7):A61K49/00;A61K43/00 |
主分类号 |
A61K51/04 |
代理机构 |
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