| 摘要 |
PURPOSE:To prepare the titled compound useful as a synthetic intermediate of pharmeceuticals, etc., relatively easily, at a low cost, in high efficiency, by hydrogenating 3-chloropropionitrile in a solvent in the presence of sulfuric acid or hydrochloric acid and a platinum-group catalyst. CONSTITUTION:The objective compound can be prepared by hydrogenating 3- chloropropionitrile in the presence of an acid selected from sulfuric acid and hydrochloric acid, a platinum-group catalyst (e.g. platinum oxide, supported palladium, etc.) and a solvent (e.g. anhydrous lower alcohol) under the hydrogen pressure of 0-50kg/cm<2>G at 0-25 deg.C. 3-Chloropropionitrile is liable to be dehalogenated by the catalytic hydrogenation, and produces a large amount of propionitrile as a byproduct. However, the production of propylamine salt by the dehalogenation reaction can be suppressed in the presence of a specific acid selected from sulfuric acid and hydrochloric acid, a specific catalyst, and a specific solvent. The amount of the acid is >=1mol, usually 1-2mol per 1mol of the raw material. |
