发明名称 |
Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals |
摘要 |
Methods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula: (HO)p-A-[-OS(O)2NR1R2]z wherein A encompasses a wide range of values including but not limited to aryl, loweralkyl, cycloalkyl, and carbohydrates including sucrose and fructose; p is equal to the number of unreacted hydroxy groups contained on the molecule and may be zero; z is the number of -OS(O)2NR1R2 groups and is always at least one; R1 and R2 are selected from hydrogen, loweralkyl, carboxy and the like; a novel process for preparing the compounds is provided wherein an appropriate sulfamic acid aryl ester is reacted with a hydroxy substituted A radical which may or may not contain thereon protected carboxyl, amino or hydroxy substituents, in an aprotic solvent containing a tertiary amine base. Pharmaceutical compositions for the treatment of chronic arthritis and osteoporosis are also provided.
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申请公布号 |
US5273993(A) |
申请公布日期 |
1993.12.28 |
申请号 |
US19920965140 |
申请日期 |
1992.11.19 |
申请人 |
A. H. ROBINS COMPANY, INCORPORATED |
发明人 |
LO, YOUNG S.;NOLAN, JOSEPH C.;WELSTEAD, JR., WILLIAM J.;WALSH, DAVID A.;SHAMBLEE, DWIGHT A.;UWAYDAH, IBRAHIM M. |
分类号 |
A61K31/255;A61K31/33;C07C307/02;C07D207/26;C07D207/27;C07D209/08;C07D211/22;C07D213/65;C07D215/26;C07D233/54;C07D277/24;C07D277/28;C07D285/10;C07D311/16;C07D319/20;C07D521/00;C07H11/00;(IPC1-7):A61K31/415 |
主分类号 |
A61K31/255 |
代理机构 |
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代理人 |
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地址 |
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