| 摘要 |
<p>NEW MATERIAL:A haloprostacyclin shown by the formulaI(R<1> is H or lower alkyl; R<2> and R<3> are H or protecting group; X is Cl, Br, or I or a pharmaceutically acceptable salt of its acid when R<1> is H. EXAMPLE:5-Bromo-DELTA<6>-PGI methyl ester. USE:A remedy or preventive for diseases resulting from thrombotic diseases. An antathmatic. An antiulcer. A hypotensor. Exhibiting an inhibiting action on blood platelet aggregation, hypotensive action, relaxing action on smooth muscle, etc. PROCESS:A prostacyclin shown by the formula II (R<11> is lower alkyl; R<21> and R<31> are protecting group) is reacted with a halogen or halogen derivative shown by the formula XQ (Q is Cl, Br, I, group shown by the formula III, formula IV, or formula V), and, if necessary, the reaction product is deprotected and/or hydrolyzed to give a compound shown by the formulaI.</p> |
