Crystalline benzothiazine dioxide salts.

摘要

The water-soluble ethylenediamine, monoethanolamine and diethanolamine salts of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide have been prepared. These novel crystalline salts are useful in therapy as nonsteroidal anti-arthritic agents. Methods for preparing these salts from the corresponding acidic starting material and the appropriate amine base are provided.