USES OF GDNF AND GDNF RECEPTOR

摘要

GDNFR alpha , GDNFR alpha extracellular domain (ECD), GDNFR alpha variants, chimeric GDNFRae (e.g., GDNFR alpha immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to GDNFR alpha -ligands, for example GDNF, by providing GDNFR alpha to the cell. Also provided are methods for using GDNFR alpha , GDNF, or agonists thereof, separately or in complex, to treat kidney diseases.