2-Aminophenol derivatives, methods for their preparation and composition containing the same.

摘要

2-Aminophenol derivatives of general formula: <CHEM> [wherein R<1> represents a straight or branched chain alkyl group containing from 1 to 6 carbon atom(s), a group represented by general formula: -(CH2)n-COOR<5> (II) (wherein R<5> represents a hydrogen atom or a straight or branched chain alkyl group containing from 1 to 4 carbon atom(s) and n represents zero or an integer from 1 to 6) or a group represented by general formula: <CHEM> (wherein R<6> represents a hydrogen atom, a halogen atom, a straight or branched chain alkyl group containing from 1 to 4 carbon atom(s), a straight or branched chain alkoxyl group containing from 1 to 4 carbon atom(s), a carbamoyl group, an alkoxycarbonyl group containing from 2 to 6 carbon atoms, a carboxyl group, an amino group, a sulfamoyl group or a cyano group and m represents zero or an integer of 1 or 2.), R<2> represents a hydroxyl group, a straight or branched chain alkoxy group containing from 1 to 4 carbon atom(s) or together with R<3> an oxo group or a hydroxyimino group. R<3> represents a hydrogen atom or together with R<2> an oxo group or a hydroxyimino group. R<4> represents a halogen atom, a straight or branched chain alkyl group containing from 1 to 6 carbon atom(s) or a phenylthio group. With the exclusion of a compound wherein R<2> and R<3> taken together represent an oxo group, R<1> represents a methyl group and R<4> represents a methyl group.] or their pharmaceutical acceptable acid addition salts which strongly inhibit 5-lipoxygenase specifically, or 5-lipoxygenase and cyclooxygenase at the same time, and are therefore useful as treating agents and preventing agents for diseases which are induced by leukotrienes e.g. allergic tracheal and bronchial diseases or allergic lung diseases, allergic shock and also various allergic inflammations which are induced by prostaglandins, and a process for their preparation and pharmaceutical compositions comprising them as active ingredients.