| 发明名称 |
SUBSTITUTED 2(2,6-DIOXOPIPERIDIN-3-YL)PHTHALIMIDES AND -1-OXOISOINDOLINES AND METHOD OF REDUCING TNF-ALPHA LEVELS |
| 摘要 |
<p>Substituted 2-(2.6-dioxopiperidin-3-yl)phthalimides and 1 -oxo-2-(2.6- dioxopiperidin-3- yl)isoindolines reduce the levels of TNF-alpha in a mammal. A typical embodiment is 1- oxo-2-(2.6-dioxopiperidin-3-yl)-4.5.6.7-tetrafluoroisoindoline having the formula: (see formula I)</p> |
| 申请公布号 |
CA2560523(A1) |
申请公布日期 |
1998.01.29 |
| 申请号 |
CA19972560523 |
申请日期 |
1997.07.24 |
| 申请人 |
CELGENE CORPORATION |
发明人 |
CHEN, ROGER SHEN-CHU;STIRLING, DAVID I.;MULLER, GEORGE W. |
| 分类号 |
C07D401/04;A61K31/4439;A61K31/445;A61K31/454;A61P1/00;A61P7/00;A61P19/00;A61P29/00;A61P37/02;A61P43/00 |
主分类号 |
C07D401/04 |
| 代理机构 |
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代理人 |
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