INDUCTION OF T CELL TOLERANCE USING A SOLUBLE MOLECULE THAT CAN SIMULTANEOUSLY BLOCK TWO COSTIMULATORY PATHWAYS

摘要

The invention provides a soluble molecule capable of binding to the human CD40 antigen and to at least the human CD86 antigen, said antigens being located on the surface of human lymphocytes, as well as vectors capable of producing the molecule and uses of the molecule in inducing T cell tolerance. Said molecule is in particular an antibody, which can be a trispecific diabody capable of binding to CD40 and to both CD80 and CD86, or a bispecific diabody capable of binding to human CD40 and to human CD86, or else a trispecific triabody capable of binding to CD40, CD80 and CD86.