| 摘要 |
3-R1-7-R2''-8-R2-9-R2'-10-R2'''-11(ax)-R3-6(eq)-R4-11(eq)-(CH2CH2CH2R5 )-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines, generally useful as morphine-like analgesics and as narcotic antagonists, are prepared by reducing, under Wolff-Kishner reaction conditions, a corresponding 3-R1-7-R2''-8-R2-9-R2'-10-R2'''-11(ax)-R3-6(eq)-R4-11(eq)-(CH2CH2COR5) -1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine and, if desired, cleaving a lower-alkoxy, methoxymethoxy or benzyloxy group to an hydroxy group. |
