发明名称 |
UV-induced factor for immunosuppression |
摘要 |
The present invention comprises the method of selectively suppressing an immune response of a mammal to a particular alloantigen. The method includes several steps. One step is administering to a mammal an effective amount of UVB-radiation. It is demonstrated herein UVB radiation selectively suppresses the DTH response in mammals. Epidermal cell cultures, when subjected to UVB irradiation (280 nm to 320 nm) produce a specific immunosuppressive factor. The immunosuppressive factor is reactive with an antibody directed toward IL-10. Another step of the inventive method involves desensitizing a mammal to a particular alloantigen. It has been determined that a mammal will become tolerant to a particular alloantigen once the subject mammal has been irradiated with a pre-determined wavelength of UVR and thereafter sensitized with the particular alloantigen. This may analogously be accomplished using the immunosuppressive factor from in vitro epidermal cell cultures of the present invention.
|
申请公布号 |
US5910309(A) |
申请公布日期 |
1999.06.08 |
申请号 |
US19950431471 |
申请日期 |
1995.05.01 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
ULLRICH, STEPHEN E. |
分类号 |
A61K38/00;A61N5/06;C07K14/54;C07K16/24;(IPC1-7):A61K41/00;A61K38/19;C07K14/52 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|