A medication infusion set comprises a housing (14) having a soft cannula (12) protruding therefrom and a self-sealing septum (36) mounted upstream of the cannula. The cannula housing is initially assembled with an insertion hub (16) having an insertion needle (18) extending through the septum and cannula for transcutaneously placing the cannula followed by separation of the insertion hub. An infusion hub (20) is then assembled with the cannula housing and includes a short infusion needle (22) for coupling the cannula with the selected medication supplied via a length of infusion tubing (24). This hub includes a protective shroud plate (26) protruding beyond the tip of the needle to minimize risk of patient contact, and slides into a shaped slot (28) formed in the cannula housing to insure a one-way and high strength interconnection between the housing and hub. Releasable latch members interlock the hub with the housing permitting periodic separation when desired.
