发明名称 STABILIZED GALLIC ACID DERIVATIVE AND EXTERNAL PREPARATION COMPOSITION CONTAINING THE SAME
摘要 PROBLEM TO BE SOLVED: To obtain a stabilized composition having skin bleaching, anti-oxidant and elasticity imparting abilities, etc., preventing discoloration and precipitation, having extremely reduced restriction of compounding composition, excellent water solubility and stability with time by using a specific gallic acid derivative. SOLUTION: This composition uses at least one selected gallic acid derivatives of the formula (R1 is H, an alkali metal, an alkaline earth metal, an ammonium salt, a 1-18C alkyl or alkenyl; R1 to R4 are each H, OH, a 1-18C alkyoxy, a polyoxyethylene, a polyoxypropylene, a monosaccharide, a disaccharide or an oligosaccharide residue) (e.g. gallic acid methyl ester-3- glucoside, etc.). The compound of the formula is obtained, for example, by using gallic acid or its ester derivative, etc., a saccharide containing an acethylated hydroxy group or a saccharide halogenated at the anomer position as starting raw materials. The objective composition contains preferably 0.05-10 wt.% of the compound of formula.
申请公布号 JP2000319116(A) 申请公布日期 2000.11.21
申请号 JP19990124878 申请日期 1999.04.30
申请人 LION CORP 发明人 MIZUSHIMA NAOKI;MATSUDA KAZUHIKO;SATO MASAHIRO;AIKI YUJIRO
分类号 C07H15/203;A61K8/18;A61K31/70;A61K31/7028;A61K31/7034;(IPC1-7):A61K7/00;A61K31/703 主分类号 C07H15/203
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