REMOVAL OF N-FORMYL PROTECTING GROUP FROM PEPTIDES WITH HYDRAZINE OR HYDRAZIDES

摘要

A process for the removal of the formyl group in N-formylated peptides or their esters is described. The N-formyl compound is reacted with hydrazine or a substituted hydrazine of formula I: at a pH between 1 and 3.5, keeping the pH constant during the reaction. The process is particularly useful for the preparation of aspartam.