Method and composition containing MCA for female sterilization

摘要

A method of female sterilization which comprises instilling methyl cyanoacrylate and radiopaque additive in the oviduct, allowing the methyl cyanoacrylate (MCA) to polymerize and induce an inflammatory response on the inside lining of the oviduct such that dense fibrous scar tissue is deposited across the oviduct lumen and the oviduct is occluded by natural scar tissue. The radiopaque additive permits the instillation to be examined by X-ray to insure proper positioning of the formulation and resultant blockage of the oviduct. The polymerized methyl cyanoacrylate degrades and is readily cleared along with other components of the formulation from the oviduct. In one embodiment the MCA and radiopaque additive are instilled together in liquid water-free form although they may also be instilled separately. The latter embodiment permits the use of aqueous systems for the radiopaque material. Acid and free radical polymerization inhibitors should also be used to prevent premature polymerization. Isobutyl cyanoacrylate may also be used with the MCA.