发明名称 |
HEPATITIS A VIRUS CELL CULTURE IN VITRO |
摘要 |
<p>16216 HEPATITIS A VIRUS CELL CULTURE IN VITRO Hepatitis A virus is passaged at least once in a susceptible sub-human primate; the infected liver from such passage is used to inoculate an in vitro cell culture, the inoculated cell culture is incubated until hepatitis A antigen is detected in the cell sheet or culture fluid, and at least two serial in vitro passages in cell culture are carried out. The hepatitis A virus so modified can be used to prepare live, attenuated hepatitis A vaccine or an inactivated hepatitis A vaccine.</p> |
申请公布号 |
CA1135621(A) |
申请公布日期 |
1982.11.16 |
申请号 |
CA19790333321 |
申请日期 |
1979.08.07 |
申请人 |
MERCK & CO., INC. |
发明人 |
PROVOST, PHILIP J.;HILLEMAN, MAURICE R. |
分类号 |
C12N7/00;A61K39/29;A61P31/12;C12R1/91;(IPC1-7):61K39/29 |
主分类号 |
C12N7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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