| 摘要 |
Aminopyrimidones I; Het=heterocycle; m=0-1; Y=methylene, O. S; n=2-3; Z=H, lower alkyl; A=C1-5 alkylene or - (CH2)p-w(CH2)q-;W=O, S; p+q=1-4; B=H, CH3 C3-6 alkyl, heteroaryl, phenyl) were prepd. as histaminic H2 receptor antagonists. Thus, 9.3g Et 2-formyl-3-(3-pyridyl)propionate was condensed with 4.7g nitroguanidine to give 38% 2-nitroamino-5-(3-pyridylmethyl)-4-pyrimidone(m.o. 214.5-216≦̸C).
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