| 摘要 |
NEW MATERIAL:The thiazolinoazetidinone derivative of formulaI[R<1> is aryl or aryloxy; R<2> is aryl(lower alkyl) which may have NO2 group at the phenyl ring, lower alkyl which may have halogen as substituent group, etc.; X<1> and X<2> are H or halogen]. USE:Useful as a synthetic intermediate of penicillin- or cephalosporin-type antibiotic substance. It can be obtained easily, under mild conditions, in high yield, without using a particular reagent nor causing the problems such as the disposal of the waste by-products, etc. PROCESS:The objective compound of formula I can be obtained by reacting an organic solvent such as dichloromethane under light irradiation. The starting raw material of formula II wherein both X<1> and X<2> are Cl can be prepared by the electrolytic chlorination of the compound of formula III. The product can be converted to another compound of formula II wherein both X<1> and X<2> are H, by treating with zinc. |
