发明名称 |
ANTIGENIC, IMMUNOGENIC HERPES VIRUS SUBUNIT AND PROCESS FOR PREPARING IT |
摘要 |
<p>Herpes virus subunit antigens suitable for vaccine use are prepared by (1) treating virus-infected cells with a surfactant and varying concentrations of salt to extract and solubilize viral-directed glycoproteins, (2) fractionating the solubilized material by chromatographic procedures to enrich the viral-directed glycoproteins and to remove unwanted proteins and nucleic acids, and (3) optionally treating the subunit antigens with deoxyribonuclease and formaldehyde to assure safety.</p> |
申请公布号 |
EP0001365(B1) |
申请公布日期 |
1982.11.10 |
申请号 |
EP19780400098 |
申请日期 |
1978.09.14 |
申请人 |
MERCK & CO. INC. |
发明人 |
LARSON, VIVIAN;LEHMAN, ERNEST DALE |
分类号 |
C12N7/00;A61K39/245;(IPC1-7):12N7/04;61K39/12 |
主分类号 |
C12N7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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