| 摘要 |
PURPOSE:To provide a drug containing a polyprenyl compound as an active component, and useful as a carcinostatic agent having low toxicity and extremely high safety and administrable without causing the problem of hypervitamin A diseases, and as a remedy for various dermatoses such as senile keratosis, etc. CONSTITUTION:The drug contains the polyprenyl compound of formulaI(n and m are 0-2; n+m is 0-2; A is group of formula II, etc.; B is group of formula III, etc.; R is hydroxyl, lower alkoxy, or group of formula IV; R1 and R2 are H, lower alkyl or aryl; provided then when n=1, m=0, A is group of formula II and B is group of formula V, that R is lower alkoxy or group of formula IV), as an active component. The compound of formulaIincludes the known compounds such as 6,10,14-trimethyl-3,5,9,13-pentadecatetraen-2-one, etc., and novel compounds such as 3,7,11,15-tetramethyl-2,4,6-hexadecatrienoic acid, etc. |
