| 摘要 |
NEW MATERIAL:The cyclohexene derivative of formulaI(R is 2-10C straight or branched-chain alkyl; X is COOH, alkoxycarbonyl or CN). EXAMPLE:1-n-Hexyl-3-cyclohexene-1-carbonitrile. USE:Drugs such as antitumor agent, antiallergic agent, hepatic function improving agent, antirheumatic agent, etc. having little side effects, and their intermediates. PROCESS:The compound of formulaIwherein X is alkoxycarbonyl or CN can be prepared by reacting the compound of formula II (X is alkoxycarbonyl or CN) with the compound of formula III (Y is halogen) in an inert solvent in the presence of a base at -78-+150 deg.C. If necessary, the product can be converted to another compound of formulaIwherein X is COOH by hydrolyzing in an aqueous alcohol in the presence of an alkali at 80-220 deg.C. |
