FORFARANDE FOR FRAMSTELLNING AV NYA ANTITUMOR-ANTRACYKLINANTIBIOTIKA BENEMNDA MA 144 MED SINA UTGIVNA FORMLER GENOM ODLING AV I OCH FOR SIG FORUT KENDA STREPTOMYCESS-STAMMAR OCH UTVINNING AV DE ANGIVNA SUBSTANSERNA

摘要

New anthracycline glycosides designated MA 144-G1, -G2, -L, -S1, -N1, -U1 and -Y which inhibit the growth of gram-positive bacteria and mammalian tumors are produced by fermentation of certain species of Streptomyces and by the chemical or enzymatic conversion of certain anthracycline glycosides. New microbiological and chemical processes are also provided for preparation of the anthracycline glycosides MA 144-S2 and -U2 which have been found to be identical with the previously reported anthracyclines, marcellomycin and musettamycin.