发明名称 |
D-PHENYLALANYL-L-PROLYL-L-ARGININE ALDEHYDE SULFATE, MANUFACTURE AND ANTICOAGULANT CONTAINING SAME |
摘要 |
<p>The invention relates to D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate, highly stable in aqueous solution, and to a process for preparing it from D-phenylalanyl-L-prolyl-L-arginine aldehyde hemisulfate or NG-carboxy derivative containing an acid-sensitive protecting group at its amino terminal, wherein the acid sensitive amino terminal protecting group or optionally the NG-carboxy group is removed with 1 to 12 N sulfuric acid, applied in 1 to 12 equivalent amounts and the resulting free tripeptide aldehyde sulfate is isolated. The D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate of the invention possesses valuable anticoagulant activity.</p> |
申请公布号 |
JPS57181046(A) |
申请公布日期 |
1982.11.08 |
申请号 |
JP19820002886 |
申请日期 |
1982.01.13 |
申请人 |
RICHTER GODEON VEGYESZETI GYAR RT |
发明人 |
SANDAA BAYOSU;ERUZEBETO SERU;EBA BARABASU;DANIIRU BADEI |
分类号 |
C07K5/08;A61K38/00;A61K38/06;A61P7/02;C07K1/06;C07K1/113;C07K5/06;C07K5/065;C07K5/087 |
主分类号 |
C07K5/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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