OSMOTIC DEVICE CONTAINING A VENLAFAXINE SALT AND A SALT HAVING A COMMON ION
摘要
The invention relates to osmotic devices comprising a single core which contains a salt of a drug and an osmotic salt, wherein the drug salt and the osmotic salt have a common ion. According to the invention, the active drug release rate is reduced and the active drug release profile is modified from a first order release profile to a zero order, pseudo zero order or sigmoidal release profile by increasing the quantity of sodium chloride in the core of the device. In one embodiment of the invention, the sodium chloride is used to modify a controlled release profile to a controlled delayed release.
申请公布号
WO2006056145(A3)
申请公布日期
2006.09.08
申请号
WO2005CR00001
申请日期
2005.01.03
申请人
OSMOTICA CORP.;FELEDER, ETHEL C.;MEYER, GLENN A.;RICCI, MARCELO A.;BEFUMO, MARCELO F.;FAOUR, JOAQUINA;PASTINI, ANA C.
发明人
FELEDER, ETHEL C.;MEYER, GLENN A.;RICCI, MARCELO A.;BEFUMO, MARCELO F.;FAOUR, JOAQUINA;PASTINI, ANA C.