| 摘要 |
NEW MATERIAL:A compound shown by the formulaI(R<1> and R<2> are H, OH, or lower alkoxy; R<3> is H or lower alkyl; R<4> is H or lower alkyl; R<5> is H, lower alkyl, or aralkyl; R<6> is OH, lower alkoxy, amino, etc.; m and n are 1 or 2), or its salt. EXAMPLE:N-( 1-Ethoxycarbonyl-8-phenylpropyl )-L-alanyl-N-( indane-2-yl )glycine hydrochloride. USE:Having inhibitory actions on an enzyme capable of converting angiotensin and an enzyme capable of decomposing bradykinin, useful as diagnosticum, preventive or remedy for hypertension, or as an anodyne. PROCESS:A compound shown by the formula II is condensed with a compound shown by the formula III by contact reduction, etc. in the presence of a catalyst such as Pt, etc., to give a compound shown by the formulaI. The reaction temperature is preferably -20-100 deg.C. The starting raw material, the compound shown by the formula II, is obtained by reducing a compound shown by the formula IV with a compound shown by the formula V. |
