| 摘要 |
<p>RAN 4038/4 "Imidazole derivatives" Tricyclic imidazole derivatives of the formula I wherein R1 signifies a 2-pyridyl group optionally substituted by lower alkyl or lower alkoxy, n signifies the number 0 or 1, R2 signifies hydrogen or lower alkyl, R3 and R4 each signify hydrogen or lower alkyl, A signifies a group of the formula -CH=CH-CH=CH- ; ; ; -(CH2)2-NH-; (a) (b) (c) (d) ; -O-(CH2)m-O- or -CH2-O-(CH2)2-O- ; (e) (f) (g) m signifies the number 2 or 3, R5, R6, R7 and R8 each signify hydrogen or lower alkyl and R9 signifies hydrogen and R10 signifies hydrogen or lower alkyl or R9 and R10 together signify an oxo group, but with the proviso that at least one of R3 and R4 signifies lower alkyl when A signifies a group of the formula -CH=CH-CH=CH- or -(CH2)4-, and their acid addition salts inhibit the gastric acid secretion and prevent the formation of ulcers. The compounds of formula I and their acid addition salts are novel; their manufacture is described. They can be brought into galenical administration forms, and they are suitable for use as medicaments.</p> |
