| 摘要 |
In a method of making a biologically compatible, water-insoluble polymeric body for the controlled, prolonged release of a biologically active substance to a surrounding aqueous environment, the method including forming a liquid mixture containing the polymer, the active substance, and an organic solvent capable of dissolving the polymer, and solidifying the liquid mixture to form the polymeric body, the improvement wherein the liquid mixture further comprises water, the solidification is carried out by cooling the liquid mixture to a temperature sufficiently low to cause the water in the mixture to freeze, thereby creating channels in the body for the release of the active substance therefrom, and removing the organic solvent and the water from the body.
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