N-Substituted 2-(8-halo and trifluoromethyl 4-quinolylamino)benzamides and analgesic use thereof

摘要

The disclosure describes new 4-aminoquinoline derivatives of general formula <IMAGE> (IV) and their pharmaceutically acceptable acid addition salts, where X is trifluoromethyl or halogen, Z is hydrogen or a defined substituent and R is a group having one of the formulae <IMAGE> (V) NR1ANR2R3 (VI) and <IMAGE> (VII) where R1 is hydrogen or lower alkyl, R2 is lower alkyl, R3 is lower alkyl and A is lower alkylene. The new 4-aminoquinoline derivatives show analgesic activity and, in some cases, anti-inflammatory activity.