| 摘要 |
<p>Pentapeptides of formula I, <IMAGE> (I) wherein Z1=H, CH3 or amidino; R1=H or alkyl and R2=H or R1+R2=-CH2-CH2-; R3=m- or p-OH or -alkoxy; B=residue of a (D)- alpha -amino acid; R4=H or alkyl; Z2=optionally substituted phenyl; and E= beta -amino alcohol residue (whereby when Z1=H or CH3, R4=C3-4-alkyl) as well as their esters and the acid addition salts and complexes of such peptides and esters. Compounds according to the invention have valuable pharmacological, in particular LH-secretion inhibiting activity.</p> |
