| 摘要 |
<p>NEW MATERIAL:A compound expressed by formula I [R<1> represents H or (halogen atom-substituted) 1-4C alkyl; R<2> and R<3> represent H or amino- protecting group; R<5> and R<6> represent (substituted)hydroxyl, or R<5> and R<6> link with each other to represent protected diol; Z represents -S- or -SO- (alpha- or beta-); dotted line binding the 2-, 3- and 4-positions shows that the compound is ceph-2-em or ceph-3-em compound, salt and solvate thereof. EXAMPLE:(6R,7R,2'Z,S)-7-[2-(2-Aminothiazol-4-yl)-2-[(carboxy) (3,4-dihydroxyphe nyl)]methoxyiminoacetamido]-3-carbamoyloxymethyl-ceph-3-em-4-carboxylic acid. USE:A remedial agent for microbism. PREPARATION:A compound (salt) expressed by formula II (R<1a> represents R<1> or N-protecting group) or 7-N-silyl derivative is acylated with an acid (salt) expressed by formula III.</p> |
