发明名称 |
Human artificial chromosome containing human antibody lambda light chain gene and non-human animal containing the human artificial chromosome capable of genetic transmission |
摘要 |
The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody lambda light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the nonhuman animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome. |
申请公布号 |
US7402729(B2) |
申请公布日期 |
2008.07.22 |
申请号 |
US20050151227 |
申请日期 |
2005.06.14 |
申请人 |
KIRIN PHARMA KABUSHIKI KAISHA |
发明人 |
KUROIWA YOSHIMI;TOMIZUKA KAZUMA;YOSHIDA HITOSHI;ISHIDA ISAO |
分类号 |
A01K67/027;A01K67/033;A61K48/00;C07K16/00;C07K16/24;C12N15/09;C12N15/85;C12N15/90;C12P21/00;C12P21/08 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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