| 摘要 |
<p>Oleandomycin antibiotics of the formula:-
<CHEM>
wherein
R1 is hydrogen or trimethylsilyl;
R2 is hydrogen or alkanoyl having from two or three carbon atoms;
Q is a group of the formula:-
<CHEM>
Z is H, OR3 COOR3, SR3 min , S(O)R3 min , S(O)2R3 min , CN or -(CH2)n-NR5R6;
X is H, CN,
<CHEM>
COOR3, SR3 min , S(O)R3 min , S(O)2R3 min ,
R3 is hydrogen alkyl having from one to four carbon atoms or
<CHEM>
R3 min is alkyl having from one to four carbon atoms or
<CHEM>
and
R4 is hydrogen, chloro, bromo, alkyl, having one to four carbon atoms or alkoxy having from one to four carbon atoms;
R5 is hydrogen or
<CHEM>
R6 is hydrogen,
<CHEM>
or R5 and R6 when taken together with the nitrogen to which they are attached represent phthalimido; and
n is 0 or 1;
and their pharmaceutically acceptable acid addition salts; processes for preparing them, and pharmaceutical compositions containing them. </p> |
