Water-soluble antitumor, antiviral and immunosuppressant compounds.

摘要

Water-soluble antitumor, antiviral and immuno-suppressant compounds the formula:
<CHEM>
wherein either R1 or R2 is a hydrogen atom, a hydroxy group, an acyloxy group, a phthalimido group or an acetamido group and the other is a hydrogen atom;
either R3 or R4 is a hydroxy group or an acyloxy group and the other is a hydrogen atom; either R5 or R6 is a hydroxy group or an acyloxy group and the other is a hydrogen atom;
either R7 or R8 is a hydrogen atom, a methyl group, a hydroxymethyl group, an acyloxymethyl group, an alkoxycarbonyl group, a group of the formula:
<CHEM>
(wherein X1 and X2 are a hydrogen atom or a lower alkyl group), or a carboxyl group and the other is a hydrogen atom; either R11 or R12 is a hydrogen atom, a hydroxy group or an acyloxy group and the other is a hydrogen atom; either R13 or R14 is a hydroxy group or an acyloxy group and the other is a hydrogen atom; and either R15 or R16 is a methyl group, a hydroxymethyl group or an acyloxymethyl group and the other is a hydrogen atom. These tautomeric compounds are prepared from the corresponding 4-carbamoylimidazolium-5-olate and carbohydrate derivatives and can be made up with conventional excipients into various dosage forms including, because of their water-solubility, injections and drops.