发明名称 |
[(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acid esters and their analogs, the parent acids and their salts |
摘要 |
The invention relates to novel [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alk anoic and cycloalkanoic acids and their analogs, esters, salts and derivatives. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful in the treatment and prevention of injury to the brain and spinal chord due to accidents, ischemic stroke and hydrocephalus; compositions for such uses are also disclosed.
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申请公布号 |
US4356313(A) |
申请公布日期 |
1982.10.26 |
申请号 |
US19810235376 |
申请日期 |
1981.02.19 |
申请人 |
MERCK & CO., INC. |
发明人 |
CRAGOE, JR., EDWARD J.;STOKKER, GERALD E.;GOULD, NORMAN P. |
分类号 |
C07C43/225;C07C45/28;C07C45/46;C07C45/66;C07C45/67;C07C45/68;C07C45/71;C07C45/73;C07C59/64;C07C59/90;C07C62/38;C07C69/734;C07D211/42;C07D211/46;C07D213/30;C07D295/088;C07D307/42;C07D317/24;(IPC1-7):C07C69/94 |
主分类号 |
C07C43/225 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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