CXCL11 ADJUVANT COMPOSITIONS AND USES THEREOF

摘要

The present invention is directed to modulating an immune response in an animal comprising administering a vaccine or pharmaceutical composition comprising an immunogen and an adjuvant which comprises a polynucleotide comprising one or more regions of nucleic acid operably encoding a CXCL11 polypeptide or fragment, variant, or derivative thereof. The present invention is further directed to modulating an immune response in an animal comprising administering a vaccine or pharmaceutical composition comprising an immunogen and an adjuvant which comprises a CXCL11 polypeptide or fragment, variant, or derivative thereof. The immune response elicited by administration of the composition of the present invention is improved relative to administration of the immunogen in the absence of the adjuvant: